Apoptotic Cell-Inspired Polymeric Particles for Controlling Microglial Inflammation toward Neurodegenerative Disease Treatment.
Yasuhiro NakagawaYuto YanoJeonggyu LeeYasutaka AnrakuMakoto NakakidoKouhei TsumotoHoracio CabralMitsuhiro EbaraPublished in: ACS biomaterials science & engineering (2019)
Apoptotic cells are known to suppress microglial inflammation in the brain by presenting phosphatidylserine. In this study, we newly designed polymeric particles that expose the anti-inflammatory site of phosphatidylserine to serve as an apoptotic cell-mimetic anti-inflammatory platform. The prepared anti-inflammatory particles showed no cytotoxicity and significantly inhibited the production of the inflammatory cytokine interleukin-6 against lipopolysaccharide stimulation in the microglia cell line MG6. This novel polymeric particle has potential for establishing a "cell-free" apoptotic cell-mimetic treatment for intracerebral inflammation.
Keyphrases
- anti inflammatory
- cell death
- oxidative stress
- inflammatory response
- single cell
- cell free
- drug delivery
- cell therapy
- lps induced
- cancer therapy
- neuropathic pain
- high throughput
- lipopolysaccharide induced
- toll like receptor
- stem cells
- cell proliferation
- risk assessment
- spinal cord
- case report
- spinal cord injury
- brain injury
- white matter
- subarachnoid hemorrhage
- smoking cessation