Transcriptomic changes during stage progression of mycosis fungoides.

Maggie Z X XiaoD HennesseyA IyerS O'KeefeF ZhangA SivanandR Gniadecki

Published in: The British journal of dermatology (2021)

Stage progression in MF is associated with Th2/Th9 polarization of malignant cells, activation of proliferation, survival, as well as increased genomic instability. Global transcriptomic changes in multiple lesions may be caused by haematogenous cell percolation between discrete skin lesions.

Keyphrases

single cell
induced apoptosis
rna seq
signaling pathway
cell cycle arrest
soft tissue
endoplasmic reticulum stress
oxidative stress
free survival
wound healing
dna methylation
genome wide
cell proliferation
mesenchymal stem cells
pi k akt