HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells.

Mansi ShahRyan CardenasBelinda WangJenny PerssonNigel P MonganAnna GrabowskaCinzia Allegrucci

Published in: Molecular cancer (2017)

Taken together, our study points to an important role of homeobox genes in breast cancer stem/progenitor cell function and establishes HOXC8 as a suppressor of stemness and transformation in the mammary gland lineage.

Keyphrases

cancer stem cells
stem cells
epithelial mesenchymal transition
genome wide
single cell
dna methylation
young adults