Mechanism of Pd-catalysed C(sp3)-H arylation of thioethers with Ag(I) additives.

Wenjing LiuZheyuan LiuXiaowei LiuYanfeng Dang

Published in: Organic & biomolecular chemistry (2022)

Mechanistic studies reveal that Pd-catalyzed C(sp3)-H arylation of thioethers with silver(i) additives takes place via C(sp3)-H activation, oxidative addition and reductive elimination, wherein all steps proceed via the heterodimeric Pd-Ag pathway. Besides, the active heterodimeric Pd-Ag species are detected by mass spectrometry via control experiments.

Keyphrases

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