An epigenomic landscape of cervical intraepithelial neoplasia and cervical cancer using single-base resolution methylome and hydroxymethylome.

Yingxin HanLiyan JiYanfang GuanMengya MaPansong LiYinge XueYinxin ZhangWanqiu HuangYuhua GongLi JiangXipeng WangHong XieBoping ZhouJiayin WangJunwen WangJinghua HanYuliang DengXin YiFei GaoJian Huang

Published in: Clinical and translational medicine (2022)

Our current study systematically delineates the map of methylome and hydroxymethylome from CINs to CC, and some differentially methylated/hydroxymethylated-associated genes can be used as the potential epigenetic biomarkers in CC prognosis.

Keyphrases

high grade
gene expression
genome wide
single cell
high density
climate change
transcription factor
bioinformatics analysis