Altered gut microbiota-host bile acid metabolism in IBS-D patients with liver depression and spleen deficiency pattern.
Liqing DuZhaozhou ZhangLixiang ZhaiShujun XuWei YangChunhua HuangChengyuan LinLinda L D ZhongZhaoxiang BianLing ZhaoPublished in: Chinese medicine (2023)
We clarified a differed BA metabolic phenotype in IBS patients with LDSD, which closely correlates with the severity of bowel symptoms. It demonstrates that gut microbiota and host co-metabolism of BAs would provide crucial insight into the biology of the LDSD pattern and its internal relationship with IBS progression.