Pharmacokinetics and Safety of Bedaquiline in Human Immunodeficiency Virus (HIV)-Positive and Negative Older Children and Adolescents With Rifampicin-Resistant Tuberculosis.

Jennifer A HughesBelén P SolansHeather R DraperH Simon SchaafJana L WincklerLouvina van der LaanKendra K RadtkeBarend FourieLubbe WiesnerAnneke C HesselingRadojka M SavicAnthony J Garcia-Prats

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)

The evaluated doses of bedaquiline in children ≥ 6 years of age were safe but achieved slightly lower plasma concentrations compared to adults receiving the recommended dose, possibly due to delayed food intake relative to bedaquiline administration.

Keyphrases

human immunodeficiency virus
hiv positive
antiretroviral therapy
drug resistant
multidrug resistant
hiv aids
hiv infected
mycobacterium tuberculosis
hepatitis c virus
men who have sex with men
pulmonary tuberculosis
south africa
emergency department