Two cases of intrahepatic cholangiocellular carcinoma with high insertion-deletion ratios that achieved a complete response following chemotherapy combined with PD-1 blockade.

Minghao SuiYu LiHongguang WangYing LuoTao WanXun WangBingyang HuYanshuang ChengXianrong LvXianlei XinQiang XuGuan WangShi-Chun Lu

Published in: Journal for immunotherapy of cancer (2019)

These two cases suggest that indels might be a new predictor of PD-1 blockade response for ICC patients beside PD-L1 expression, TMB, MSI, and dMMR, warranting further clinical investigation.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
locally advanced