Association of Sirtuin Gene Polymorphisms with Susceptibility to Coronary Artery Disease in a North Chinese Population.

Xingfa SongHaidong WangChao WangGuangquan JiPei Jiang Donglou Liang Xiaojing Wang

Published in: BioMed research international (2022)

The SNP rs28365927 in the SIRT3 gene and SNP rs350844, rs350846, and rs107251 in the SIRT6 gene present significant associations with CAD in a north Chinese population. Haplotype CTA and GCG generated by rs350846/rs107251/rs350844 in the SIRT6 might also increase and decrease the risk of CAD, respectively.

Keyphrases

coronary artery disease
genome wide
oxidative stress
type diabetes
dna methylation
cardiovascular disease
acute coronary syndrome
cardiovascular events
coronary artery bypass grafting
transcatheter aortic valve replacement
high density
aortic stenosis
ejection fraction