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Whole body physiology model to simulate respiratory depression of fentanyl and associated naloxone reversal.

Austin BairdSteven A WhiteRishi DasNathan TatumErika K Bisgaard
Published in: Communications medicine (2024)
This paper investigates the total naloxone dose needed to properly reverse respiratory depression associated with fentanyl overdose. We show that the current guidelines for a rescue dose may be much lower than required.
Keyphrases
  • depressive symptoms
  • sleep quality
  • respiratory tract
  • clinical practice
  • physical activity