Cardiomyocyte precursors generated by direct reprogramming and molecular beacon selection attenuate ventricular remodeling after experimental myocardial infarction.

Dipthi Bachamanda SomeshKristin KloseJanita A MaringDésirée KunkelKarsten JürchottStephanie I ProtzeOliver KleinGrit NebrichMatthias BeckerUlrike KrügerTimo Z Nazari-ShaftiVolkmar FalkAndreas KurtzManfred GossenChristof Stamm

Published in: Stem cell research & therapy (2023)

Fibroblast reprogramming combined with molecular beacon-based cell selection yields an iCMP-like cell population with cardioprotective potential. Further studies are needed to elucidate mechanism-of-action and translational potential.

Keyphrases

single cell
heart failure
cell therapy
left ventricular
stem cells
human health
bone marrow
wound healing
case control