Comprehensive multiplexed immune profiling of the ductal carcinoma in situ immune microenvironment regarding subsequent ipsilateral invasive breast cancer risk.
Mathilde M M AlmekindersTycho BismeijerTapsi KumarFei YangBram ThijssenRianne van der LindenCharlotte van RooijenShiva VonkBaohua SunEdwin Roger Parra CuentesIgnacio I WistubaSavitri KrishnamurthyLindy L VisserIris M SeignetteIngrid HoflandJoyce SandersAnnegien BroeksJason K LoveBrian A MenegazLodewyk WesselsAlastair M ThompsonKarin E de VisserErik HooijbergEsther H LipsP Andrew FutrealJelle Wesselingnull nullPublished in: British journal of cancer (2022)
IME features analysed by mIF in 141 patients from a well-annotated cohort of pure DCIS with long-term follow-up are no predictors of subsequent iIBC, but do correlate with other factors (grade, ER, HER2 status, Ki-67) known to be associated with invasive recurrences.