Validation of Rapid Magnetic Resonance Myelin Imaging in Multiple Sclerosis.

Russell A OuelletteGabriel MangeatIldiko PolyakMarcel WarntjesYngve ForslinÅsa BergendalMichael PlatténMartin UppmanConstantina Andrada TreabaJulien Cohen-AdadFredrik PiehlMaria Kristoffersen WibergSten FredriksonCaterina MaineroTobias Granberg

Published in: Annals of neurology (2020)

Rapid Estimation of Myelin for Diagnostic Imaging provides robust myelin quantification that detects diffuse demyelination in normal-appearing tissue in multiple sclerosis, which is associated with both cognitive and clinical disability. Because the technique is fast, with automatic postprocessing and US Food and Drug Administration/CE clinical approval, it can be a clinically feasible biomarker that may be suitable to monitor myelin dynamics and evaluate treatments aiming at remyelination. ANN NEUROL 2020;87:710-724.

Keyphrases

multiple sclerosis
white matter
drug administration
magnetic resonance
high resolution
deep learning
computed tomography
neural network
risk assessment
mass spectrometry