Aggf1 Specifies Hemangioblasts at the Top of Regulatory Hierarchy via Npas4l and mTOR-S6K-Emp2-ERK Signaling.

Zhongcheng YangDi GuoJinyan ZhaoJia LiRui ZhangYidan ZhangChengqi Xu Tie Ke Qing Kenneth Wang

Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)

and becomes the earliest marker during specification of hemangioblasts. Our data identify a novel signaling axis of Aggf1 (angiogenic factor with G-patch and FHA domain 1)-mTOR-S6K-ERK1/2 for specification of hemangioblasts and HSPCs, primitive and definitive hematopoiesis, and vascular development. Our findings provide important insights into specification of hemangioblasts and HSPCs essential for the development of the circulation system.

Keyphrases

cell proliferation
signaling pathway
cell fate
pi k akt
electronic health record
machine learning
locally advanced