DNA repair gene polymorphisms, tumor control, and treatment toxicity in prostate cancer patients treated with permanent implant prostate brachytherapy.
Damien CarignanTrystan LessardLyne VilleneuveSylvie DesjardinsSindy MagnanPhilippe DesprésAndré-Guy MartinWilliam FosterChantal GuillemetteÉric LévesqueEric VigneaultPublished in: The Prostate (2020)
This study suggests an association of the intronic variants of the DNA nucleotide excision repair ERCC3 and DNA mismatch repair MSH2 genes with elevated risk of BCR and late urinary toxicity respectively after LDRB. Further validation is required before translational clinical advances.
Keyphrases
- dna repair
- prostate cancer
- dna damage
- circulating tumor
- cell free
- single molecule
- oxidative stress
- radical prostatectomy
- dna damage response
- high dose
- radiation therapy
- acute lymphoblastic leukemia
- nucleic acid
- copy number
- gene expression
- dna methylation
- squamous cell carcinoma
- benign prostatic hyperplasia
- combination therapy
- bioinformatics analysis
- genome wide analysis