17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma.
Constanze A JakwerthMarkus WeckmannSabina IlliHelen CharlesUlrich M ZisslerMadlen OelsnerFerdinand GuerthJimmy OmonySai Sneha Priya NemaniRuth GrychtolAnna-Maria DittrichChrysanthi SkevakiSvenja FothStefanie WeberMiguel A Alejandre AlcazarSilke van Koningsbruggen-RietschelRobert BrockSamira BlauGesine HansenThomas BahmerKlaus F RabeFolke BrinkmannMatthias Volkmar KoppAdam M ChakerBianca SchaubErika von MutiusCarsten B Schmidt-Webernull nullPublished in: American journal of respiratory and critical care medicine (2023)
-related airway cell death and perturbations in the mucosal IFN signature account for the increased vulnerability of 17q21 risk allele carriers to respiratory viral infections during early life, opening new options for future biological interventions.