Outcomes of Infants and Young Children With Relapsed Medulloblastoma After Initial Craniospinal Irradiation-Sparing Approaches: An International Cohort Study.
Craig ErkerMartin MynarekSimon BaileyClaire M MazewskiLorena V BaroniMaura MassiminoJuliette HukinDolly AguileraAndrea Maria CappellanoVijay RamsawamiÁlvaro Lassaleta-AtienzaSébastien PerreaultCassie N KlineRevathi RajagopalGeorge MichaielMichal ZapotockyVicente Santa-MariaAndrés Morales La MadridChantel CacciottiEric S SandlerLindsey M HoffmanDarren KlawinskiSara KhanRalph SalloumAnna L HoppmannValérie LaroucheKathleen DorrisHelen ToledanoStephen W GilheeneyMohamed S AbdelbakiBeverly WilsonDerek S TsangJeffrey KnipsteinMichal Yalon OrenShafqat ShahJeffrey C MurrayKevin F GinnZhihong J WangGudrun FleischhackDenise ObrechtSvenja TonnVirginia L HarrodKara MathesonBruce CrooksDouglas R StrotherKenneth J CohenJordan R HansfordRomain MuellerAshley S MargolAmar J GajjarGirish DhallJonathan L FinlayPaul A NorthcottStefan RutkowskiSteven C CliffordGiles W RobinsonEric BouffetLucie Lafay-CousinPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)
A substantial proportion of patients with relapsed iMB are salvaged after initial CSI-sparing approaches. Patients with SHH subgroup, localized relapse, older age at initial diagnosis, and those receiving salvage CSI show improved PRS. Future prospective studies should investigate optimal CSI doses and the role of salvage chemotherapy in this population.