No impact of polymorphism in the phosphodiesterase 5A gene in Cavalier King Charles Spaniels on pimobendan-induced inhibition of platelet aggregation response.
Maria Josefine ReimannDaniel N FaisstMads KnoldKathryn M MeursJoshua A SternSigne E CremerJacob E MøllerIngrid LjungvallJens HäggströmLisbeth Høier OlsenPublished in: Journal of veterinary internal medicine (2023)
The PDE5A:E90K polymorphism did not influence in vitro basal platelet aggregation response or the inhibitory effect of pimobendan on platelet aggregation in CKCS. Dogs with the PDE5A:E90K polymorphism did not appear to have altered platelet function or response to pimobendan treatment.