Abnormal p53 and p16 staining patterns distinguish uterine leiomyosarcoma from inflammatory myofibroblastic tumour.

Inga-Marie SchaeferJason L HornickLynette M ShollBradley J QuadeMarisa R NucciCarlos Parra-Herran

Published in: Histopathology (2017)

Abnormal p53 staining and p16 loss are observed frequently in uterine leiomyosarcomas, with 100% specificity and 70% sensitivity against IMT, and correlating with genomic alterations. Conversely, IMT shows normal p53 and p16 staining, highlighting the use of these markers in the differential diagnosis of uterine mesenchymal neoplasms.

Keyphrases

flow cytometry
stem cells
oxidative stress
structural basis