Development of a biodegradable prosthesis through tissue engineering, for the organ-replacement or substitution of the extrahepatic bile duct.
Alan I Valderrama-TreviñoAndrés E Castell-RodríguezRolando Hernández-MuñozNadia A Vázquez-TorresAndrés Macari-JorgeBaltazar Barrera-MeraAlfredo Maciel-CerdaRicardo Vera-GrazianoNatalia Nuño-LámbarriEduardo E Montalvo-JavéPublished in: Annals of hepatology (2024)
A tubular scaffold composed of electrospun PGLA-PCL-Gel nanofibers was used for the first time to replace the extrahepatic bile duct in pigs. Mechanical and biological evaluations indicate that this scaffold is biocompatible and biodegradable, making it an excellent candidate for use in bile ducts and potentially in other tissue engineering applications.