Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement.
Cecilie HenkelUnnur StyrkársdóttirGudmar ThorleifssonLilja StefánsdóttirGyda BjörnsdóttirKarina BanasikSøren BrunakChristian ErikstrupKhoa Manh DinhThomas Folkmann HansenKaspar René NielsenMie Topholm BruunJoseph DowsettThorsten Brodersennull nullThorgeir E ThorgeirssonKirill GromovMikael Ploug BoesenHenrik UllumSisse Rye OstrowskiOle Birger PedersenKári StefánssonAnders TroelsenPublished in: Annals of the rheumatic diseases (2022)
Our results indicate differences in genetic associations between knee and hip osteoarthritis depending on joint replacement status.
Keyphrases
- knee osteoarthritis
- systematic review
- total knee arthroplasty
- end stage renal disease
- genome wide association
- rheumatoid arthritis
- ejection fraction
- genome wide
- newly diagnosed
- chronic kidney disease
- total hip arthroplasty
- prognostic factors
- meta analyses
- anterior cruciate ligament reconstruction
- dna methylation
- patient reported outcomes
- case control