Breaking bad.

Mohini Bhattacharya Alexander R Horswill

Published in: The Journal of experimental medicine (2023)

DNASE1 (D1) and DNASE1L3 (D1L3) synergistically reduce the severity of systemic infections caused by Staphylococcus aureus. In this issue of JEM, Lacey et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20221086) develop D1-/-, D1L3-/-, and D1-/-D1L3-/- mice to show that exogenous addition of the DNase formulation Dornase alfa can facilitate removal of biofilms.

Keyphrases

staphylococcus aureus
drug delivery
candida albicans
type diabetes
high fat diet induced
biofilm formation
escherichia coli
skeletal muscle
pseudomonas aeruginosa
cystic fibrosis