Defective FGFR1 Signaling Disrupts Glucose Regulation: Evidence From Humans With FGFR1 Mutations.
Maria I StamouCrystal J ChiuShreya V JadhavVanessa Ferreira LopesKathryn B SalnikovLacey PlummerMargaret F LippincottHang LeeStephanie B SeminaraRavikumar BalasubramanianPublished in: Journal of the Endocrine Society (2024)
These findings suggest that impaired FGFR1 signaling may contribute to an early insulin resistance phase of diabetes pathogenesis and support the candidacy of the FGFR1 signaling pathway as a therapeutic target for improving the human metabolic health.
Keyphrases
- insulin resistance
- signaling pathway
- type diabetes
- endothelial cells
- healthcare
- public health
- cardiovascular disease
- mental health
- adipose tissue
- glycemic control
- metabolic syndrome
- pi k akt
- high fat diet
- blood glucose
- epithelial mesenchymal transition
- induced pluripotent stem cells
- skeletal muscle
- cell proliferation
- polycystic ovary syndrome
- oxidative stress
- social media
- health promotion
- human health