Fronto-striatal circuits for cognitive flexibility in far from onset Huntington's disease: evidence from the Young Adult Study.
Christelle LangleySarah GregoryKatie CrowleyClaire O'CallaghanPaul ZeunJessica LoweEileanoir B JohnsonMarina PapoutsiRachael I ScahillGeraint ReesSarah J TabriziTrevor William RobbinsBarbara Jacquelyn SahakianPublished in: Journal of neurology, neurosurgery, and psychiatry (2020)
We postulate that this incipient impairment of cognitive flexibility may be associated with intrinsically abnormal functional connectivity of fronto-striatal circuitry in pre-HD.