A Novel Mouse Model of Idiopathic Nephrotic Syndrome Induced by Immunization with the Podocyte Protein Crb2.
Ichiro HadaAkira ShimizuHiromu TakematsuYukino NishiboriToru KimuraToshiyuki FukutomiAkihiko KudoNoriko Ito-NittaZentaro KiuchiJaakko PatrakkaNaoaki MikamiSimon LeclercYoshihiro AkimotoYoshiaki HirayamaSatoka MoriTomoko TakanoKunimasa YanPublished in: Journal of the American Society of Nephrology : JASN (2022)
The results highlight the causative role of anti-Crb2 autoantibody in podocyte injury in mice. Crb2 immunization could be a useful model to study the immunologic pathogenesis of human INS, and may support the role of autoimmunity against podocyte proteins in INS.