Studying individual risk factors for self-harm in the UK Biobank: A polygenic scoring and Mendelian randomisation study.
Kai Xiang LimFrühling Vesta RijsdijkSaskia P HagenaarsAdam SocratesShing Wan ChoiJonathan R I ColemanKylie P GlanvilleCathryn M LewisJean-Baptiste PingaultPublished in: PLoS medicine (2020)
In addition to confirming the role of MDD, we demonstrate that ADHD and schizophrenia likely play a role in the aetiology of self-harm using multivariate genetic designs for causal inference. Among the many individual risk factors we simultaneously considered, our findings suggest that systematic detection and treatment of core psychiatric symptoms, including psychotic and impulsivity symptoms, may be beneficial among people at risk for self-harm.
Keyphrases
- bipolar disorder
- risk factors
- major depressive disorder
- attention deficit hyperactivity disorder
- mental health
- sleep quality
- autism spectrum disorder
- working memory
- single cell
- gene expression
- depressive symptoms
- copy number
- obsessive compulsive disorder
- dna methylation
- combination therapy
- real time pcr
- case control