Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC.
Rajashree MishraMikael ÅkerlundDiana L CousminerEmma AhlqvistJonathan P BradfieldAlessandra ChesiKenyaita M HodgeVanessa C GuyDavid J BrillonRichard E PratleyMichael R RickelsAdrian VellaFernando OvalleRonald I HarrisOlle MelanderStephen VarvelHakon H HakonarsonPhillippe FroguelJohn T LonsdaleEsmeralda CastelblancoNanette C SchlootKamlesh Khunti F MedSciCarla J GreenbaumKnud B YderstrædeTiinamaija TuomiBenjamin F VoightStanley SchwartzBernhard O BoehmLeif GroopRichard David LeslieStruan F A GrantPublished in: Diabetes care (2019)
In LADA, the independent effects of MHC class I observed in type 1 diabetes were not observed after conditioning on the leading MHC class II associations, suggesting that the MHC class I association may be a genetic discriminator between LADA and childhood-onset type 1 diabetes.