Zeolitic Imidazolate Framework-8 Encapsulating Risedronate Synergistically Enhances Osteogenic and Antiresorptive Properties for Bone Regeneration.
Xinting ChengZhou ZhuYanhua LiuYiyuan XueXiaomeng GaoJian WangXibo PeiQianbing WanPublished in: ACS biomaterials science & engineering (2020)
Bisphosphonates (BPs) are routinely administered for the treatment of turnover bone diseases. To avoid the undesirable adverse effects of long-term usage of bisphosphonates and improve their bioavailability in the bone microenvironment, we initially encapsulated risedronate (RIS) molecules inside nanoscale zeolitic imidazolate framework-8 particles (nZIF-8) by a one-step synthesis method to generate RIS@ZIF-8 nanoparticles. RIS@ZIF-8 nanoparticles displayed high loading encapsulation efficiency (64.21 ± 2.48%), good biocompatibility, controlled drug release capacity, and dual effects for bone regeneration. This work explored the potential of RIS@ZIF-8 nanoparticles, which could not only enhance ATP production, induce extracellular matrix (ECM) mineralization, and upregulate the expression levels of osteogenic genes but also effectively inhibit the formation of multinucleated giant osteocasts and decrease the Rankl/Opg ratio. Overall, RIS@ZIF-8 nanoparticles could be a very promising approach to synergistically enhance osteogenic and antiresorptive properties for bone regeneration, which could be utilized for the local treatment of bone defects.
Keyphrases
- bone regeneration
- extracellular matrix
- mesenchymal stem cells
- bone marrow
- drug release
- stem cells
- bone mineral density
- drug delivery
- emergency department
- walled carbon nanotubes
- genome wide
- immune response
- inflammatory response
- dna methylation
- toll like receptor
- postmenopausal women
- high resolution
- atomic force microscopy
- replacement therapy
- single molecule
- smoking cessation
- metal organic framework
- soft tissue