YTHDF1 promotes intrahepatic cholangiocarcinoma progression via regulating EGFR mRNA translation.

Xiang HuangLefan ZhuLina WangWenjie HuangLi TanHaining LiuJihui HuoTianhong SuMengping ZhangMing KuangXiaoxing LiZihao DaiLixia Xu

Published in: Journal of gastroenterology and hepatology (2022)

A reader-dependent mechanism of YTHDF1 in regulation of ICC progression. Restricting abnormal oncogenic mRNA translation by targeting YTHDF1 may be a novel and promising strategy for ICC treatment.

Keyphrases

small cell lung cancer
binding protein
epidermal growth factor receptor
tyrosine kinase
transcription factor
combination therapy