Impact of Frontline Ivosidenib on Volumetric Growth Patterns in Isocitrate Dehydrogenase (IDH) mutant Astrocytic and Oligodendroglial Tumors.

David Olayinka Kamson Sushant Puri Yingying Sang Meihui Jessica Shi Lindsay Blair Jaishri O Blakely John Laterra

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Ivosidenib was well-tolerated and induced a high volumetric response rate. Responders had significant reduction in tumor growth rates and volume reductions observed after a 5-month delay. Thus, ivosidenib appears useful to control tumor growth and delay more toxic therapies in IDH-mutant non-enhancing indolently growing gliomas.

Keyphrases

wild type
high grade
high glucose
low grade
diabetic rats
drug induced