GIP Affects Hepatic Fat and Brown Adipose Tissue Thermogenesis but Not White Adipose Tissue Transcriptome in Type 1 Diabetes.
Sebastian Møller Nguyen HeimbürgerBjørn HoeChris Neumann NielsenNatasha Chidekel BergmannKirsa Skov-JeppesenBolette HartmannJens Juul HolstFlemming DelaJulie OvergaardJoachim StørlingTina VilsbøllThomas Fremming DejgaardJesper Foged HavelundVladimir A GorshkovFrank KjeldsenNils Joakim FærgemanMartin Rønn MadsenMikkel Bring ChristensenFilip K Krag KnopPublished in: The Journal of clinical endocrinology and metabolism (2022)
Six days of subcutaneous GIP infusion in men with type 1 diabetes transiently decreased bone resorption and increased NEFA and β-oxidation. Further, hepatic fat content, and supraclavicular skin temperature were increased without affecting WAT transcriptomics, the circulating proteome, lipids, or inflammatory markers.
Keyphrases
- adipose tissue
- insulin resistance
- type diabetes
- single cell
- high fat diet
- soft tissue
- rna seq
- bone loss
- bone mineral density
- low dose
- hydrogen peroxide
- cardiovascular disease
- gene expression
- glycemic control
- genome wide
- middle aged
- wound healing
- nitric oxide
- dna methylation
- metabolic syndrome
- body composition
- postmenopausal women
- electron transfer