In situ embedding dual-Fe nanoparticles in synchronously generated carbon for the synergistic integration of magnetic resonance imaging and drug delivery.
Hui ZhangJianping ZhangQianqian ZhangXiaofeng LiuYongtai YangYun LingYaming ZhouPublished in: Nanoscale advances (2020)
In situ incorporating versatile magnetic iron nanoparticles into ordered mesoporous carbon (OMC) by means of synthetic methodology for functional integration is a great challenge. Inspired by the phenomenon of uniovular twins in nature, a homometallic [Fe 9 (μ 3 -O) 4 (O 3 PPh) 3 (O 2 CCMe 3 ) 13 ] ({Fe 9 P 3 }) cluster was synthesized and used as the ovulum to in situ produce dual-Fe nanoparticle (γ-Fe 2 O 3 and Fe(PO 3 ) 3 )-functionalized OMC (dual-Fe/OMC). In vitro magnetic resonance imaging (MRI) studies showed a longitudinal relaxation ( r 1 ) and transverse relaxation ( r 2 ) of 9.74 and 26.59 mM -1 s -1 with a r 2 / r 1 ratio of 2.73 at 0.5 T. The MRI performances were further examined by mouse model with a subcutaneous HeLa tumor. In addition, the low cytotoxicity, considerable loading capacity and delivery of doxorubicin hydrochloride (DOX) were also studied in vitro . These results demonstrate the feasibility of the concept of uniovular twins in the one-pot preparation of dual-Fe/OMC for functional integration.