COVID-associated non-vasculitic thrombotic retiform purpura of the face and extremities: A case report.

Connor M BunchNuha ZackariyaAnthony V ThomasJack H LangfordMichael AboukhaledSamuel J ThomasAida AnsariShivani S PatelHallie BucknerJoseph B MillerChristy L AnnisMargaret A Quate-OperaczLeslie A SchmitzJoseph J PulvirentiJonathan C KonopinskiKathleen M KelleySamer HassnaLuke G NelliganMark M Walsh

Published in: Clinical case reports (2022)

SARS-CoV-2 infection can manifest many rashes. However, thrombotic retiform purpura rarely occurs during COVID-19 illness. Aggressive anti-COVID-19 therapy with a high-dose steroid regimen led to rapid recovery. This immunothrombotic phenomenon likely represents a poor type 1 interferon response and complement activation on the endothelial surface in response to acute infection.

Keyphrases

coronavirus disease
sars cov
high dose
respiratory syndrome coronavirus
liver failure
low dose
endothelial cells
dendritic cells
respiratory failure
stem cell transplantation
immune response
stem cells
soft tissue
cell therapy
mesenchymal stem cells
acute respiratory distress syndrome