Improved T-cell Immunity Following Neoadjuvant Chemotherapy in Ovarian Cancer.
Min LiuNabihah TayobLivius PenterMacLean SellarsAnna TarrenVipheaviny CheaIsabel CarulliTeddy HuangShuqiang LiSu-Chun ChengPhuong LeLaura FrackiewiczJulia FasseCourtney QiJoyce F LiuElizabeth H StoverJennifer CurtisKenneth J LivakDonna S NeubergGuanglan ZhangUrsula A MatulonisCatherine J WuDerin B KeskinPanagiotis A KonstantinopoulosPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
NACT may alleviate tumor-associated immunosuppression by reducing tumor burden and may enhance antigen processing and presentation. These findings have implications for the successful combinatorial applications of immune checkpoint blockade and therapeutic vaccine approaches in EOC.