Feasibility assessment of inspiration breath-hold motion management for tumor tracking during cone-beam computed tomography for setup and radiotherapy in Veterinary Medicine: A pilot study.
Keiko MurakamiNicholas J RancilioLisa FosterPublished in: Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association (2024)
Radiotherapy (RT) for lung or liver tumors can be challenging due to respiration-induced organ motion (RIOM). There are some methodological solutions to minimize RIOM. We explored a new approach to evaluate the feasibility and reproducibility of RIOM during RT with five total client-owned tumor-bearing animals using a remote-triggered breath-hold ventilator under general anesthesia during image acquisition and RT. There was one stereotactic body radiotherapy, one conventionally fractionated definitive intent, and three conventionally fractionated palliative intent RT cases. Based on repeated cone beam CT, there were no treatment table shifts required prior to initiating beam on. No clinically significant complications such as hypotension occurred during anesthesia. This technique appeared to be safe in this group of patients and was easily clinically implemented and highly reproducible. More complete follow-up data and larger studies are needed to evaluate clinical outcomes with this breath-hold ventilator technique in veterinary RT.
Keyphrases
- locally advanced
- early stage
- radiation therapy
- end stage renal disease
- cone beam computed tomography
- cone beam
- radiation induced
- newly diagnosed
- chronic kidney disease
- ejection fraction
- acute respiratory distress syndrome
- computed tomography
- electronic health record
- squamous cell carcinoma
- deep learning
- patient reported outcomes
- risk factors
- magnetic resonance
- big data
- mass spectrometry
- positron emission tomography
- stress induced