The effect of epigallocatechin-3-gallate on morphine-induced memory impairments in rat: EGCG effects on morphine neurotoxicity.

S SaffarIman FatemiM RahmaniJ HassanshahiA SahamsizadehM AllahtavakoliV SheibaniAyat Kaeidi

Published in: Human & experimental toxicology (2020)

Our data indicate that EGCG can improve memory in morphine-treated rats. Molecular mechanisms underlying the detected effects could be related to the prevention of apoptosis and oxidative stress in the hippocampus of morphine-treated rats.

Keyphrases

oxidative stress
diabetic rats
working memory
dna damage
endoplasmic reticulum stress
ischemia reperfusion injury
electronic health record
induced apoptosis
high glucose
cell cycle arrest
cognitive impairment
newly diagnosed
cerebral ischemia
prefrontal cortex
pi k akt
heat shock