Extracellular tyrosyl-tRNA synthetase cleaved by plasma proteinases and stored in platelet α-granules: Potential role in monocyte activation.

Eric WonYosuke MorodomiSachiko KanajiRyan ShapiroMy-Nuong VoJennifer N OrjeCourtney Dawn ThornburgXiang-Lei YangZaverio M RuggeriPaul SchimmelTaisuke Kanaji

Published in: Research and practice in thrombosis and haemostasis (2020)

Platelets take up both full-length YRS and the active form of cleaved YRS fragment from the plasma. The cleaved, N-terminal YRS fragment stored in α-granules may have potential to activate monocytes.

Keyphrases

dendritic cells
room temperature
peripheral blood
endothelial cells
human health
red blood cell