Alterations of plasma exosomal proteins and motabolies are associated with the progression of castration-resistant prostate cancer.

Pengyu LiuWenxuan WangFei WangJiaqi FanJinan GuoTao WuDongliang LuQingchun ZhouZhuohao LiuYuliang WangZhiqun ShangFranky Leung ChanWei YangXin LiShan-Chao ZhaoQingyou ZhengFei WangDinglan Wu

Published in: Journal of translational medicine (2023)

Integration of proteomics and metabolomics data generated proteomic and metabolic signatures of plasma exosomes that may facilitate discrimination of CRPC from PCa and TFC patients, suggesting the potential of exosomal proteins and metabolites as CRPC markers. The study also confirmed the important role of exosomal protein LRG1 in PCa malignant progression.

Keyphrases

end stage renal disease
mass spectrometry
ejection fraction
newly diagnosed
chronic kidney disease
mesenchymal stem cells
stem cells
peritoneal dialysis
ms ms
prognostic factors
dna methylation
climate change
bone marrow
patient reported
artificial intelligence
human health