Cucurbitacin B Diminishes Metastatic Behavior of Cholangiocarcinoma Cells by Suppressing Focal Adhesion Kinase.

Putthaporn KaewmeesriVeerapol KukongviriyapanAuemduan PrawanSarinya KongpetchLaddawan Senggunprai

Published in: Asian Pacific journal of cancer prevention : APJCP (2021)

FAK participated in regulation of metastatic behavior of KKU-452 CCA cells. Cucurbitacin B suppressed FAK activation in the cells which was associated with inhibition of metastasis essential steps and their related metastatic proteins. The compound may be developed as a novel therapeutic agent for CCA metastasis therapy.<br />.

Keyphrases

induced apoptosis
cell cycle arrest
squamous cell carcinoma
small cell lung cancer
endoplasmic reticulum stress
signaling pathway
oxidative stress
cell death
cell proliferation
pi k akt
cell therapy
drug induced
protein kinase
biofilm formation