Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues.

Courtney W HannaRaquel Pérez-PalaciosLenka GahurovaMichael SchubertFelix KruegerLaura BigginsSimon AndrewsMaria Colomé-TatchéDeborah Bourc'hisWendy DeanGavin Kelsey

Published in: Genome biology (2019)

This study reveals distinct epigenetic mechanisms regulating non-canonical imprinted gene expression between embryonic and extra-embryonic development and identifies an integral role for ERVK LTR repetitive elements.

Keyphrases

gene expression
dna methylation
genome wide
high frequency