Integrated approach to functional analysis of an ERBB2 variant of unknown significance detected by a cancer gene panel test.

Yohei HaradaAkemi SatoMitsugu ArakiShigeyuki MatsumotoYuta IsakaYukari SagaeTomonori AbeYasuko AoyagiEisaburo SueokaYasushi OkunoShinya KimuraNaoko Sueoka-Aragane

Published in: Cellular oncology (Dordrecht) (2022)

Our results provide important information on the activating mechanisms of ERBB2 extracellular domain (ECD) variants and illustrate a model workflow integrating wet and dry bench processes for the analysis of VUS detected with cancer gene panel tests.

Keyphrases

papillary thyroid
copy number
squamous cell
genome wide
tyrosine kinase
healthcare
dna methylation
lymph node metastasis
childhood cancer
electronic health record
health information
social media
genome wide analysis