Runt-related transcription factor-1 ameliorates bile acid-induced hepatic inflammation in cholestasis through JAK/STAT3 signaling.

Liangjun Zhang Qiong Pan Lu Zhang Haihan Xia Junwei Liao Xiaoxun Zhang Nan Zhao Min Liao Ya Tan Qiao Li Jinfei Zhu Ling Li Shijun Fan Jian-Wei Li Chengcheng Zhang Shi-Ying Cai James L Boyer Jin Chai

Published in: Hepatology (Baltimore, Md.) (2023)

This study has gained initial evidence establishing the functional role of hepatocyte RUNX1 in alleviating liver inflammation during cholestasis through JAK/STAT3 signaling. Modulating hepatic RUNX1 activity could be a new therapeutic target for cholestasis.

Keyphrases

transcription factor
drug induced
liver injury
oxidative stress
dna binding
genome wide identification