Sirt6-Mediated Cell Death Associated with Sirt1 Suppression in Gastric Cancer.

Ji Hyun SeoSomi RyuSo Young CheonSeong-Jun LeeSeong-Jun WonChae Dong YimHyun-Jin Lee Young-Sool Hah Jung Je Park

Published in: Cancers (2024)

We found that the upregulation of Sirt6 suppressed Sirt1, and Sirt6- and Sirt1-induced gastric cancer cell death was mediated by ROS production. These findings highlight the potential of Sirt6 and Sirt1 as therapeutic targets for treating gastric cancer.

Keyphrases

cell death
oxidative stress
ischemia reperfusion injury

cell proliferation
risk assessment
diabetic rats

high glucose
endothelial cells

cell cycle arrest
human health