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Sirt6-Mediated Cell Death Associated with Sirt1 Suppression in Gastric Cancer.

Ji Hyun SeoSomi RyuSo Young CheonSeong-Jun LeeSeong-Jun WonChae Dong YimHyun-Jin LeeYoung-Sool HahJung Je Park
Published in: Cancers (2024)
We found that the upregulation of Sirt6 suppressed Sirt1, and Sirt6- and Sirt1-induced gastric cancer cell death was mediated by ROS production. These findings highlight the potential of Sirt6 and Sirt1 as therapeutic targets for treating gastric cancer.
Keyphrases
  • cell death
  • oxidative stress
  • ischemia reperfusion injury
  • cell proliferation
  • risk assessment
  • diabetic rats
  • high glucose
  • endothelial cells
  • cell cycle arrest
  • human health