Sirt6-Mediated Cell Death Associated with Sirt1 Suppression in Gastric Cancer.
Ji Hyun SeoSomi RyuSo Young CheonSeong-Jun LeeSeong-Jun WonChae Dong YimHyun-Jin LeeYoung-Sool HahJung Je ParkPublished in: Cancers (2024)
We found that the upregulation of Sirt6 suppressed Sirt1, and Sirt6- and Sirt1-induced gastric cancer cell death was mediated by ROS production. These findings highlight the potential of Sirt6 and Sirt1 as therapeutic targets for treating gastric cancer.