Effect of moderate elevated intra-abdominal pressure on lung mechanics and histological lung injury at different positive end-expiratory pressures.

Mascha Onida FiedlerB Luise DeutschEmilis SimeliunasDovile DiktanaiteAlexander HarmsMaik BruneFlorian UhleMarkus WeigandThorsten BrennerArmin Kalenka

Published in: PloS one (2020)

A moderate elevated IAP of 10 mmHg leads to relevant changes in lung mechanics during mechanical ventilation. In our study, a PEEP of 10 cmH2O was associated with a lower lung injury score and was able to overcome the IAP induced alterations of EELV.

Keyphrases

mechanical ventilation
acute respiratory distress syndrome
intensive care unit
high intensity
respiratory failure
high glucose
diabetic rats
extracorporeal membrane oxygenation
endothelial cells