A Theranostic Probe for Promotion of Skin Wound Healing by Exudate-Triggered H 2 S Release with Self-Monitoring Ability.

Hydrogen sulfide (H 2 S) as an endogenous gasotransmitter plays a critical role in promotion of wound healing. However, the current H 2 S release system lacks the in situ monitoring ability, which may lead to insufficient or overdose release of H 2 S and serious side effects. Herein, we develop a self-monitoring theranostic probe TPATCF-S, which can quickly release H 2 S under water stimuli associated with a self-monitoring ability by a color change from colorless to deep blue. With a full thickness dermal defect as a model, the TPATCF-S absorbed on alginate dressings can be used for wound exudate-responsive release of H 2 S to efficiently promote skin wound healing.