ANGPTL4 Promotes the Proliferation of Papillary Thyroid Cancer via AKT Pathway.

Longyan YangYan WangRongxin SunYuanyuan ZhangYing FuZhaohui ZhengZhili JiDong Zhao

Published in: OncoTargets and therapy (2020)

Our findings suggested that ANGPTL4 was increased in PTC compared with adjacent noncancerous tissues, and ANGPTL4 increased cell proliferation and inhibited cell cycle arrest in PTC cells via promoting AKT phosphorylation. The study may provide fundamental information to suggest its suitability as a target for the treatment of PTC.

Keyphrases

cell cycle arrest
pi k akt
signaling pathway
cell proliferation
cell death
induced apoptosis
cell cycle
gene expression
endoplasmic reticulum stress