Girls' brain structural connectivity in late adolescence relates to history of depression symptoms.
Rajpreet ChahalDavid G WeissmanScott MarekShawn A RhoadsAlison E HipwellErika E ForbesKate E KeenanAmanda E GuyerPublished in: Journal of child psychology and psychiatry, and allied disciplines (2019)
Higher depressive symptom severity in early adolescence and increasing symptom severity over time may forecast structural connectivity differences in late adolescence, particularly in pathways involving cognitive and emotion-processing regions. Understanding how clinical course relates to neurobiological correlates may inform new treatment approaches to adolescent depression.