Triple Primary Cancers: An Analysis of Genetic and Environmental Factors.

Nicholas A Borja Rachel Silva-Smith Carmen J Calfa Daniel A Sussman Mustafa Tekin

Published in: Cancer prevention research (Philadelphia, Pa.) (2024)

In patients with three or more primary cancers, genetic predisposition explained a significant proportion of cases; however, treatment history, lifestyle habits, and other exposures appeared to play a less significant role. This highlights the value of early genetic screening and the need to develop more sensitive markers of cancer susceptibility. See related Spotlight, p. 193.

Keyphrases

genome wide
copy number
metabolic syndrome
papillary thyroid
cardiovascular disease
physical activity
weight loss
squamous cell carcinoma
type diabetes
dna methylation
gene expression
childhood cancer
young adults
lymph node metastasis
smoking cessation