Anulamycins A-F, Cinnamoyl-Containing Peptides from a Lake Sediment Derived Streptomyces .
Han WangHuan QiHui ZhangShao-Yong ZhangCheng-Hong ZhangLi-Qin ZhangWen-Sheng XiangJi-Dong WangPublished in: Journal of natural products (2023)
Bioinformatics analysis of a whole genome sequence coupled with HPLC-DAD analysis revealed that Streptomyces sp. Hu103 has the capacity to produce skyllamycin analogues. A subsequent chemical investigation of this strain yielded four new cinnamoyl-containing cyclopeptides, anulamycins A-D ( 1 - 4 ), two new cinnamoyl-containing linear peptides, anulamycins E and F ( 5 and 6 ), and two known cyclopeptides, skyllamycins A ( 7 ) and B ( 8 ). Their structures including absolute configurations were elucidated by detailed analysis of NMR and HRESIMS/MS spectroscopic data and the advanced Marfey's method. Compounds 1 - 4 exhibited antibacterial activity comparable to those of skyllamycins A and B.
Keyphrases
- ms ms
- molecular docking
- simultaneous determination
- high resolution
- mass spectrometry
- amino acid
- magnetic resonance
- multiple sclerosis
- electronic health record
- high performance liquid chromatography
- single cell
- tandem mass spectrometry
- polycyclic aromatic hydrocarbons
- big data
- solid phase extraction
- silver nanoparticles
- solid state
- data analysis
- liquid chromatography
- organic matter