Exercise Mitigates Endothelial Pyroptosis and Atherosclerosis by Downregulating NEAT1 Through N6-Methyladenosine Modifications.

Qingyuan YangShiliang ChenXingyi WangXinyu YangLiangqi ChenTuo HuangYang ZhengXianghui ZhengXiaojun WuYong Sun Jian Wu

Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)

Our study of NEAT1 provides new insights into the improvement of atherosclerosis by exercise. This finding demonstrates the role of exercise-mediated NEAT1 downregulation in atherosclerosis while expanding our understanding of the mechanisms by which exercise regulates long noncoding RNA function through epigenetic modifications.

Keyphrases

high intensity
long noncoding rna
physical activity
cardiovascular disease
resistance training
dna methylation
gene expression
type diabetes
signaling pathway
cell proliferation
radiation therapy
radiation induced